Method for preparing epidemic hemorrhagic fever vaccine

制备流行性出血热疫苗的方法

Abstract

一种采用长爪沙鼠的肾细胞作病毒培养基质制备流行性出血热疫苗的方法,适用于汉坦(Hanta)病毒属中任何一种型别的病毒株。培养后加入β-丙内酯和硫柳汞对病毒灭活,离心去除细胞碎片,再加入氢氧化铝和人血白蛋白,成为单价流行性出血热疫苗。将两种或者三种不同型别单价疫苗半成品等量混合,配制分装,成为双价或者多价流行性出血热疫苗。
A method for preparing epidemic hemorrhagic fever vaccine by using the kidney cell of long-paw sand mouse as virus cultivating medium is suitable for all types of virus strain of Hanta virus. After cultivation, the virus is deactivated by adding Beta-propyl lactone and thimerosal, centrifugalized to eliminate cell fragment, and added with aluminum hydroxide and human blood albumin to become univalent epidemic hemorrhagic fever vaccine. Two or three different kinds of univalent vaccine may be equivalently mixed and packaged into bivalent or polyvalent epidemic hemorrhagic fever vaccine.

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Cited By (2)

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    CN-100553676-COctober 28, 2009徐怀英;秦卓明;王友令H9亚型禽流感hi稳定抗原
    CN-101732709-BMarch 14, 2012浙江天元生物药业有限公司一种多层培养瓶培养原代细胞制备出血热疫苗的方法